mineralocorticoid receptor การใช้
- They are also activated by supraphysiologic stimulation of the mineralocorticoid receptor.
- Aldosterone, probably acting through mineralocorticoid receptors, may positively influence neurogenesis in the dentate gyrus.
- Mineralocorticoid receptor blockers, such as spironolactone, coupled with potassium supplementation are the most commonly used treatments.
- Amlodipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.
- Nifedipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.
- Nimodipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.
- Nitrendipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.
- Benidipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.
- PTSD mothers and children illustrate lower basal cortisol levels and glucocorticoid receptors and increased mineralocorticoid receptors when exposed to stress.
- EEF1A1 is downregulated in myocardial infarction and potentially participates in cardiovascular disease through its interactions with mineralocorticoid receptors in the heart.
- Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor, leading to aldosterone-like effects in the kidney.
- In these tissues, HSD11B2 oxidizes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.
- In addition to its glucocorticoid activity, mometasone also has very potent progestogenic activity and acts as a partial agonist of the mineralocorticoid receptor.
- Mineralocorticoid receptor inhibition is responsible for the desired action of the drugs, whereas inhibition of the other receptors potentially leads to side effects.
- Aldosterone and cortisol ( a glucosteroid ) have similar affinity for the mineralocorticoid receptor; however, glucocorticoids circulate at roughly 100 times the level of mineralocorticoids.
- Deactivation of enzymatic activity reduces aldosterone concentrations in plasma and tissues which decreases mineralocorticoid receptor-dependent and independent effects in cardiac vascular and renal target organs.
- In the brain, cortisol acts on two types of receptor mineralocorticoid receptors and glucocorticoid receptors, and these are expressed by many different types of neurons.
- Activation of the mineralocorticoid receptor, upon the binding of its ligand aldosterone, results in its transcription into mRNA of the DNA sequence of the activated genes.
- In addition to the glucocorticoid properties of mometasone furoate, it is a very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor.
- Having published over 500 scientific papers, Funder is an expert in mineralocorticoid receptors and aldosterone biology and serves as a consultant to many pharmaceutical companies engaged in this field.
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